Ketamine-assisted psychotherapy involves the use of Ketamine to aid the psychotherapeutic process. Ketamine has been safely and legally used as an anesthetic for decades, and is used off-label for the treatment of mental health conditions. A significant body of research shows KAP is an effective treatment for depression, and can be particularly effective when other treatments have failed.

At low doses, Ketamine can cause an opening and relaxation that aids the therapeutic process, and at higher doses it can produce a psychedelic experience that can be the basis for transformation. Ketamine may facilitate neuroplasticity, allowing the brain to make new connections and rewire old habits and thoughts.

KAP is typically done in six dosing sessions or less, and involves therapeutic preparation beforehand and integration afterwards.